Tampa Bay Rays vs Cleveland Guardians Prediction 8/27/2025 Today’s MLB Picks

The Tampa Bay Rays and the Cleveland Guardians meet Wednesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tampa Bay Rays vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Tampa Bay Rays will start Drew Rasmussen here and Rasmussen is 10-5 with a 2.62 ERA and 108 strikeouts this season. In his career, Rasmussen is 0-0 with a 1.80 ERA and 5 strikeouts against Cleveland. Slade Cecconi will start this game for Cleveland is 5-6 with a 4.41 ERA and 79 strikeouts this season. This will be Cecconi’s first career start against Tampa Bay.

Tampa Bay Rays Recap

The Tampa Bay Rays come into this game looking to rebound from a 3-0 loss at the hands of the Guardians on Tuesday to fall to 64-68 this season. After this series, the Rays will head on the road for a series against the Washington Nationals.

Rays Have Three-Game Win Streak Snapped

Jonathan Aranda has 113 hits with 22 doubles, 12 home runs and 54 RBIs. Brandon Lowe has 107 hits with 25 homers and 63 RBIs as well while Junior Caminero has 124 hits with 21 doubles, a team-high 37 home runs and 91 RBIs. Yandy Diaz has 135 hits with 22 doubles, 21 homers and 73 RBIs.

Why the Tampa Bay Rays will win

• The Guardians have lost eight of their last nine day games against teams that held a losing record.
• The Rays have won each of their last five Wednesday day games against AL Central opponents.
• The Guardians have failed to cover the run line each of their last seven day games against American League opponents that held a losing record.
• The Rays have covered the run line in seven of their last eight road games against AL Central opponents that held a losing record.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has hit a home run in each of the Rays’ last two games as road favorites against AL opponents.
• Drew Rasmussen has recorded five or more strikeouts in seven of his last eight appearances with the Rays as favorites against AL opponents.
• Brandon Lowe has recorded at least one hit in each of his last 11 appearances with the Rays as road favorites.
• Drew Rasmussen has recorded a win in each of his last three appearances with the Rays as road favorites.
• Yandy Diaz has recorded a Double in four of the Rays’ last five road games against AL opponents.
• Chandler Simpson ranks 2nd in the league in Steals (38) this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Rays on Tuesday to improve to 65-66 this season. After this series, the Guardians will take on the Seattle Mariners in a series at home.

Guardians Snap Six-Game Skid

Steven Kwan has 134 hits as part of a .275 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 83 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 121 strikeouts and Manzardo has 105 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 26 home runs and 68 RBIs with 36 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

• The Guardians have won five of their last six games as home underdogs against the Rays.
• The Rays have lost four of their last five games as favorites against the Guardians following a road loss.
• The Guardians have covered the run line in each of their last 11 Wednesday games as underdogs.
• The Rays have failed to cover the run line in each of their last five day games against American League opponents.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in each of his last two appearances with his team as a home underdog against the Rays.
• Steven Kwan has recorded at least one hit in each of his 10 previous appearances in day games against AL East teams that held a losing record.
• Jose Ramirez ranks 3rd in the league in Steals (36) this season.

Total Runs Facts

• Nine of the last 10 games between the Rays and Guardians have gone UNDER the total runs line.
• Five of the Rays’ last six games as favorites against American League opponents have gone OVER the total runs line.

Tampa Bay Rays vs. Cleveland Guardians Prediction

I’m backing the Rays in this one. The Guardians got the win on Tuesday, but it was one bad inning that did in the Rays in that game, but the Guardians for the most part have had issues with scoring as of late and with Rasmussen being on the mound for Tampa Bay, I think that the Rays have an advantage in pitching here and get their get back over the Guardians on Wednesday. I’ll roll with the Rays in this one.