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Tampa Bay Rays vs Cleveland Guardians Prediction 8/27/2025 Today’s MLB Picks

Aug 24, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) hits a grand slam against the St. Louis Cardinals in the fifth inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Aug 24, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) hits a grand slam against the St. Louis Cardinals in the fifth inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

MATCHUP Tampa Bay Rays Cleveland Guardians
Team Records 64-68 65-66
Where Progressive Field, Cleveland, Ohio
When Wednesday, August 27, 2025
Time 01:10 PM EDT
TV CLEGuardians.TV

The Tampa Bay Rays and the Cleveland Guardians meet Wednesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tampa Bay Rays vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Tampa Bay Rays will start Drew Rasmussen here and Rasmussen is 10-5 with a 2.62 ERA and 108 strikeouts this season. In his career, Rasmussen is 0-0 with a 1.80 ERA and 5 strikeouts against Cleveland. Slade Cecconi will start this game for Cleveland is 5-6 with a 4.41 ERA and 79 strikeouts this season. This will be Cecconi’s first career start against Tampa Bay.

Tampa Bay Rays Recap

The Tampa Bay Rays come into this game looking to rebound from a 3-0 loss at the hands of the Guardians on Tuesday to fall to 64-68 this season. After this series, the Rays will head on the road for a series against the Washington Nationals.

Rays Have Three-Game Win Streak Snapped

Jonathan Aranda has 113 hits with 22 doubles, 12 home runs and 54 RBIs. Brandon Lowe has 107 hits with 25 homers and 63 RBIs as well while Junior Caminero has 124 hits with 21 doubles, a team-high 37 home runs and 91 RBIs. Yandy Diaz has 135 hits with 22 doubles, 21 homers and 73 RBIs.

Why the Tampa Bay Rays will win

Tampa Bay Rays Player Prop Facts

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their win over the Rays on Tuesday to improve to 65-66 this season. After this series, the Guardians will take on the Seattle Mariners in a series at home.

Guardians Snap Six-Game Skid

Steven Kwan has 134 hits as part of a .275 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 83 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 121 strikeouts and Manzardo has 105 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 26 home runs and 68 RBIs with 36 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Total Runs Facts

Tampa Bay Rays vs. Cleveland Guardians Prediction

I’m backing the Rays in this one. The Guardians got the win on Tuesday, but it was one bad inning that did in the Rays in that game, but the Guardians for the most part have had issues with scoring as of late and with Rasmussen being on the mound for Tampa Bay, I think that the Rays have an advantage in pitching here and get their get back over the Guardians on Wednesday. I’ll roll with the Rays in this one.

Chris Ruffolo's Pick: Tampa Bay -125

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