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Toronto Blue Jays vs Seattle Mariners Prediction 10/16/2025 Today’s MLB Picks

Oct 15, 2025; Seattle, Washington, USA; Toronto Blue Jays fans celebrate after the game against the Seattle Mariners during game three of the ALCS round for the 2025 MLB playoffs at T-Mobile Park. Mandatory Credit: Steven Bisig-Imagn Images

Oct 15, 2025; Seattle, Washington, USA; Toronto Blue Jays fans celebrate after the game against the Seattle Mariners during game three of the ALCS round for the 2025 MLB playoffs at T-Mobile Park. Mandatory Credit: Steven Bisig-Imagn Images

MATCHUP Toronto Blue Jays Seattle Mariners
Team Records 94-68 90-72
When Thursday, October 16, 2025
Time 08:33 PM EDT
TV FS1

The Toronto Blue Jays and Seattle Mariners meet Thursday in MLB Game 4 ALCS action at T-Mobile Park. Here’s a Toronto Blue Jays vs Seattle Mariners Prediction. This article will include a Toronto Blue Jays vs Seattle Mariners Pick.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays look to win another road game to even up the series at 2-2. The Toronto Blue Jays are batting .300 on the season, have a .350 OBP, and a .545 slugging percentage. The Toronto Blue Jays pitching staff has a 4.94 ERA and a 1.35 WHIP. Vladimir Guerrero Jr. leads the Toronto Blue Jays with 13 hits and 10 RBI while Ernie Clement and Daulton Varsho have combined for 21 hits and 12 RBI.

Max Scherzer gets the ball for the Toronto Blue Jays, and he is 5-5 with a 5.19 ERA and 82 strikeouts this season. Scherzer is 7-8 with a 3.78 ERA and 171 strikeouts in his postseason career. Scherzer is 4-2 with a 2.97 ERA and 55 strikeouts in his career against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners look to take a 3-1 series lead and become a game away from a World Series berth. The Seattle Mariners are batting .219 on the season, have a .298 OBP, and a .392 slugging percentage. The Seattle Mariners pitching staff has a 3.99 ERA and a 1.15 WHIP. Cal Raleigh leads the Seattle Mariners with 11 hits and 6 RBI, while Josh Naylor and Jorge Polanco have combined for 18 hits and 10 RBI.

Luis Castillo gets the ball for the Seattle Mariners, and he is 11-8 with a 3.54 ERA and 162 strikeouts this season. Castillo is 2-2 with a 1.40 ERA and 23 strikeouts in his postseason career. Castillo is 2-3 with a 4.68 ERA and 31 strikeouts in his career against the Toronto Blue Jays.

Why the Seattle Mariners will win

Why the Toronto Blue Jays will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Toronto Blue Jays Player Prop Facts

Matchup/League Facts

Toronto Blue Jays vs Seattle Mariners Prediction

The Blue Jays finally found their offense in their game 3 victory and if that carries over we’ll be going back to Canada evened up. However, Castillo has been money lately, allowing 18 hits and 8 runs in his last 35.1 innings. The Mariners have won 6 straight games with Castillo on the mound. Castillo has a 2.60 ERA and .192 allowed batting average in 100.1 home innings. Scherzer is a Hall of Famer and has been in endless big games, but he’s allowed 24 hits and 17 runs in his last 15 innings. In 35 road innings, Scherzer has a 5.91 ERA and .252 allowed batting average. At 41 years old, Scherzer is a shell of himself. I’ll side with the Mariners for a bounce back performance.

Randy Chambers's Pick: Seattle Mariners

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