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Washington Nationals vs New York Mets Prediction 9/21/2025 Today’s MLB Picks

Sep 19, 2025; New York City, New York, USA; New York Mets first baseman Pete Alonso (20) follows through on a single against the Washington Nationals during the first inning at Citi Field. Mets shortstop Francisco Lindor (not pictured) scored on the play on an error by Nationals right fielder Dylan Crews (not pictured). Mandatory Credit: Brad Penner-Imagn Images

Sep 19, 2025; New York City, New York, USA; New York Mets first baseman Pete Alonso (20) follows through on a single against the Washington Nationals during the first inning at Citi Field. Mets shortstop Francisco Lindor (not pictured) scored on the play on an error by Nationals right fielder Dylan Crews (not pictured). Mandatory Credit: Brad Penner-Imagn Images

MATCHUP Nationals Washington Mets New York
Team Records 64-92 80-76
Where Citi Field, Queens, New York
When Sunday, September 21, 2025
Time 01:40 PM EDT
TV MLB.TV

The Washington Nationals and the New York Mets meet Sunday in MLB action from Citi Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Washington Nationals vs. New York Mets prediction.

Starting Pitching Matchup

The Washington Nationals will send out Jake Irvin here and Irvin is 8-13 with a 5.76 ERA and 113 strikeouts this season. In his last five starts against the Mets, Irvin is 0-3 with a 5.12 ERA and 18 strikeouts. Sean Manaea will get the nod for the Mets here and is 2-3 with a 5.40 ERA and 68 strikeouts this season. In his last five starts against the Nationals, Manaea is 1-2 with a 3.49 ERA and 27 strikeouts.

Washington Nationals Recap

The Washington Nationals come into this game looking to add on to their 5-3 win over the Mets from Saturday’s matchup to sit at 63-92 this season. After this series, the Nationals will take to the road for a division series against the Atlanta Braves.

Nationals Snap Eight Game Slide

James Wood has 145 hits with 37 doubles and a team-high 27 home runs along with 89 RBIs and 15 stolen bases while also putting up 212 strikeouts. CJ Abrams has 145 hits with 18 home runs and 58 RBIs along with 34 doubles and 31 stolen bases while Luis Garcia Jr. has 28 doubles and 13 stolen bases of his own this season. Josh Bell also has 104 hits with 14 doubles, 20 home runs and 61 RBIs this season.

New York Mets Recap

The New York Mets come into this game looking to bounce back from their loss to the Nats from Saturday’s matchup to sit at 80-75 on the year. After this set, the Mets will go on the road for a series against the Chicago Cubs.

Mets Looking To Salvage Series Rubber Match

Pete Alonso has 161 hits with 37 doubles, 37 home runs, 122 RBIs and a .272 batting average while Juan Soto has 145 hits with 19 doubles, 34 stolen bases, 42 home runs and 103 RBIs on the year. Francisco Lindor has 164 hits with 30 stolen bases along with 34 doubles, 27 home runs and 79 RBIs while Mark Vientos has 17 home runs and 58 RBIs, but also has 107 strikeouts so far this season. Brandon Nimmo has also added 145 hits with 27 doubles and 24 home runs and 88 RBIs this season. Luis Torrens has also chipped in 13 doubles and Luisangel Acuna has 15 stolen bases as well this season.

Washington Nationals @ New York Mets Betting Trends: September 21, 2025

Why the New York Mets will win

Why the Washington Nationals will win

Total Runs Facts

New York Mets Player Prop Facts

Washington Nationals Player Prop Facts

Matchup/League Facts

Washington Nationals vs. New York Mets Prediction

I’m on the over in this one. You have two starting pitchers in Sean Manaea and Jake Irvin that I really don’t trust to do their jobs in any given start, and also two bullpens that I don’t trust to be able to hold it down in the event that these starters actually come out and throw well. I think we’re headed for some runs in Sunday’s finale so give me the over here.

Chris Ruffolo's Pick: Over 8.5

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