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Buffalo Bills vs New England Patriots Prediction NFL Picks 1/5/25

Tina MacIntyre-Yee/Democrat and Chronicle / USA TODAY NETWORK via Imagn Images

New England Patriots (3-13) vs Buffalo Bills (13-3)

Game Info: Sunday, January 5, 2025 at 1:00 pm (Gillette Stadium)

The Line: Betting Odds: New England Patriots +2.5 / Buffalo Bills -2.5 — Over/Under: 38.5

(Get latest betting odds)

In this article, we will formulate a Buffalo Bills vs New England Patriots prediction for this NFL game on Sunday, January 5th at Gillette Stadium in Foxborough, Massachusetts. Let’s take a look at the prediction for this week 18 matchup.

Buffalo Bills Betting Preview

The Buffalo Bills are 13-3 this year after they defeated the Jets by a score of 40-14 in their last game. Buffalo scored the first 40 points in the game, but they did allow 14 late points to ruin the shutout. The Bills outgained New York by a total of 348-281, won the turnover battle 3-0, and went 8-14 on third down in the game. Josh Allen threw for 182 yards and two touchdowns, while James Cook rushed for 53 yards and one score in the game. 

Prior to that win, the Bills defeated the Patriots by a score of 24-21 and the Lions by a score of 48-42. Buffalo has won three games in a row and 10 of their last 11, and they have clinched the AFC East Title. The Buffalo offense has scored 31.8 points per game with 234.1 passing yards and 131.3 rushing yards per game, while the defense has allowed 21.6 points per game this season. Josh Allen has completed 63.6% of his passes for 3,731 yards, 28 touchdowns, and six interceptions, while Khalil Shakir has caught 76 passes for 821 yards and four scores this year. Buffalo does plan to rest some of their starters for this game, so that needs to be monitored as we get closer to kickoff. 

New England Patriots Betting Preview

The New England Patriots are 3-13 this season after they lost to the Chargers by a score of 40-7 in their last game. New England cut the deficit to 17-7 in the second quarter, but they were outscored 23-0 the rest of the way for the blowout loss. The Patriots were outgained by a total of 428-181, lost the turnover battle 1-0, and went 2-10 on third down in the game. Drake Maye threw for 117 yards and one touchdown, while DeMario Douglas caught four passes for 46 yards and one score in the loss. 

Prior to that game, the Patriots lost to the Bills by a score of 24-21 and the Cardinals by a score of 30-17. New England has lost six games in a row and they are last in the AFC East standings, one game behind the Jets. The New England offense has scored 16.6 points per game with 172.6 passing yards and 118.3 rushing yards per game, while the defense has allowed 25.1 points per game this season. Drake Maye has completed 66.8% of his passes for 2,276 yards, 15 touchdowns, and 10 interceptions, while Hunter Henry has caught 66 passes for 674 yards and two scores this year. It is possible the Patriots will turn to a different quarterback in this game, but I think it will most likely be Maye under center. 

Why the Bills will beat the Patriots

Total Points Facts

New England Patriots Player Prop Facts

Buffalo Bills Player Prop Facts

Matchup/League Facts

Buffalo Bills vs New England Patriots Prediction 

Buffalo comes into this matchup with nothing to play for in this game, so their focus will be keeping everyone healthy. New England also has no incentive to win this game, as they are currently lined up for the #1 pick in the NFL Draft. The Patriots did play Buffalo tough just a couple of games ago and they will be at home, but I don’t see them messing up their draft pick. That #1 pick is too valuable for them or for a team that wants to trade with them, so I think they are going to really try to play conservatively here. Take the Bills to get the win. 

David Racey's Pick: Bills ML

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