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Denver Broncos vs Los Angeles Chargers Prediction 9/21/2025 Today’s NFL Picks

Sep 15, 2025; Paradise, Nevada, USA; Los Angeles Chargers running back Omarion Hampton (8) catches a pass during warm ups before the game against the Las Vegas Raiders at Allegiant Stadium. Mandatory Credit: Stephen R. Sylvanie -Imagn Images

Sep 15, 2025; Paradise, Nevada, USA; Los Angeles Chargers running back Omarion Hampton (8) catches a pass during warm ups before the game against the Las Vegas Raiders at Allegiant Stadium. Mandatory Credit: Stephen R. Sylvanie -Imagn Images

MATCHUP Broncos Denver Chargers Los Angeles
Team Records 1-2 3-0
Where SoFi Stadium, Inglewood, CA
When Sunday, September 21, 2025
Time 04:05 PM EDT
TV CBS

The Denver Broncos and Los Angeles Chargers meet Sunday in NFL action at SoFi Stadium. Here’s a Denver Broncos vs Los Angeles Chargers Prediction. This article will include a Denver Broncos vs Los Angeles Chargers Pick.

Denver Broncos Betting Preview

The Denver Broncos beat the Titans, lost to the Colts, and they play the Bengals next. The Denver Broncos have won 6 of their last 9 games. Bo Nix is completing 67.1 percent of his passes for 382 yards, 4 touchdowns, and 3 interceptions. Troy Franklin and Courtland Sutton have combined for 200 receiving yards and 2 touchdowns, while Marvin Mims Jr. has 5 receptions.

The Denver Broncos ground game is averaging 134.5 yards per contest, and J.K. Dobbins leads the way with 139 yards and 2 touchdowns. Defensively, Denver is allowing 20.5 points and 303 yards per game. Talanoa Hufanga leads the Denver Broncos with 21 tackles, Justin Strnad has 2 sacks and Riley Moss has 3 pass deflections.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers beat the Chiefs and Raiders, and they play the Giants next. The Los Angeles Chargers have won 5 straight regular season games. Justin Herbert is completing 72.1 percent of his passes for 560 yards, 5 touchdowns, and 0 interceptions. Quentin Johnston and Keenan Allen have combined for 279 receiving yards and 5 touchdowns, while Ladd McConkey has 11 receptions.

The Los Angeles Chargers ground game is averaging 85.5 yards per contest, and Omarion Hampton leads the way with 72 yards on 23 carries. Defensively, Los Angeles is allowing 15 points and 282.5 yards per game. Daiyan Henley leads the Los Angeles Chargers with 18 tackles, Khalil Mack has 1 sack and Donte Jackson has 1 interception.

Denver Broncos @ Los Angeles Chargers Betting Trends: Week 3

Why the Los Angeles Chargers will win

Why the Denver Broncos will win

Total Points Facts

Los Angeles Chargers Player Prop Facts

Denver Broncos Player Prop Facts

Matchup/League Facts

Denver Broncos vs Los Angeles Chargers Prediction

The Chargers are going to get the love from oddsmakers at home, and they’re the sexier team with the high-powered offense. However, I see value in the Broncos in the underdog role given they have one of the best defenses in the league, and they should be eager to rebound from a tough loss to the Colts. The Chargers have less time to prepare for this game, and they’re banged up on defense, with Denzel Perryman and Khalil Mack on the injury report. Four of the last 10 games between the Chargers and Broncos have been decided by 3 or fewer points. I want the points with the Broncos in a game they could win outright.

Randy Chambers's Pick: Denver Broncos +2.5

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