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Detroit Lions vs Baltimore Ravens Prediction 9/22/2025 Today’s NFL Picks

Sep 14, 2025; Baltimore, Maryland, USA; Baltimore Ravens running back Derrick Henry (22) is tackled by Cleveland Browns defensive end Myles Garrett (95) during the first quarter at M&T Bank Stadium. Mandatory Credit: Peter Casey-Imagn Images

Sep 14, 2025; Baltimore, Maryland, USA; Baltimore Ravens running back Derrick Henry (22) is tackled by Cleveland Browns defensive end Myles Garrett (95) during the first quarter at M&T Bank Stadium. Mandatory Credit: Peter Casey-Imagn Images

MATCHUP Lions Detroit Ravens Baltimore
Team Records 1-1 1-1
Where M&T Bank Stadium, Baltimore, MD
When Monday, September 22, 2025
Time 08:15 PM EDT
TV ABC

The Detroit Lions and Baltimore Ravens meet Monday in NFL action at M&T Bank Stadium. Here’s a Detroit Lions vs Baltimore Ravens Prediction. This article will include a Detroit Lions vs Baltimore Ravens Pick.

Detroit Lions Betting Preview

The Detroit Lions lost to the Packers, beat the Bears, and play the Browns next. The Detroit Lions have won 15 of their last 17 regular season games. Jared Goff is completing 80.6 percent of his passes for 559 yards, 6 touchdowns, and 1 interception. Amon-Ra St. Brown and Jameson Williams have combined for 291 receiving yards and 4 touchdowns, while Sam LaPorta has 9 receptions.

The Detroit Lions ground game is averaging 111.5 yards per contest, and Jahmyr Gibbs leads the way with 113 yards and 1 touchdown. Defensively, Detroit is allowing 24 points and 302.5 yards per game. Jack Campbell leads the Detroit Lions with 18 tackles, Aidan Hutchinson has 1 sack and Kerby Joseph has 1 interception.

Baltimore Ravens Betting Preview

The Baltimore Ravens lost to the Bills, beat the Browns, and they play the Chiefs next. The Baltimore Ravens have won 5 of their last 6 regular season games. Lamar Jackson is completing 68.8 percent of his passes for 434 yards, 6 touchdowns, and 0 interceptions. Zay Flowers and DeAndre Hopkins have combined for 317 receiving yards and 3 touchdowns, while Devontez Walker has 2 receptions.

The Baltimore Ravens ground game is averaging 141.5 yards per contest, and Derrick Henry leads the way with 192 yards and 2 touchdowns. Defensively, Baltimore is allowing 29 points and 409.5 yards per game. Roquan Smith leads the Baltimore Ravens with 25 tackles, Nnamdi Madubuike has 2 sacks and Nate Wiggins has 1 interception.

Detroit Lions @ Baltimore Ravens Betting Trends: Week 3

Why the Baltimore Ravens will win

Why the Detroit Lions will win

Total Points Facts

Baltimore Ravens Player Prop Facts

Detroit Lions Player Prop Facts

Matchup/League Facts

Detroit Lions vs Baltimore Ravens Prediction

The Ravens are going to be favored at home, as you can make a case they’re the best team in the league. I wouldn’t talk you off the ledge if looking at the Ravens and the reasonable number. However, the Lions are a good team in their own right despite what a rocky start has shown, and you’re not going to get them as an underdog often. The Lions have also covered 10 of their last 12 games as an underdog, and 7 of those covers were outright wins. The Lions have covered 8 of their last 9 games when an underdog of 3 or more points. As high as I am on the Ravens, I just can’t leave this many points on the table with the Lions, a talented team that’s been Super Bowl caliber for the last few years. Give me the points.

Randy Chambers's Pick: Detroit Lions +4.5

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