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Houston Texans vs Jacksonville Jaguars Prediction 9/21/2025 Today’s NFL Picks

Sep 15, 2025; Houston, Texas, USA;  Houston Texans quarterback C.J. Stroud (7) drops back to pass during the first quarter against the Tampa Bay Buccaneers at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images

Sep 15, 2025; Houston, Texas, USA; Houston Texans quarterback C.J. Stroud (7) drops back to pass during the first quarter against the Tampa Bay Buccaneers at NRG Stadium. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Texans Houston Jaguars Jacksonville
Team Records 0-3 2-1
Where EverBank Stadium, Jacksonville, FL
When Sunday, September 21, 2025
Time 01:00 PM EDT
TV CBS

The Houston Texans and the Jacksonville Jaguars meet in week 3 NFL action from EverBank Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Texans vs. Jacksonville Jaguars prediction.

Houston Texans Recap

The Houston Texans come into this game looking to rebound from their 20-19 loss at the hands of the Tampa Bay Buccaneers last time out to sit at 0-2 on the year. After this game, the Texans will head home for another division game against the Tennessee Titans.

Texans Searching For First W

C.J. Stroud has thrown for 395 yards, a touchdown and an interception on 62.7% passing while Nick Chubb has rushed for 103 yards and a touchdown. Nico Collins leads Houston’s receivers with 6 grabs for 77 yards and a touchdown as well on the year. On defense, Henry To’oTo’o and Azeez Al-Shaair each have 17 total tackles with Al-Shahir logging a team-high 11 solo tackles. Derek Stingley Jr. and Will Anderson Jr. each have a pair of sacks as well this season.

Jacksonville Jaguars Recap

The Jacksonville Jaguars come into this game looking to rebound from their 31-27 loss to the Cincinnati Bengals last time out to sit at 1-1 on the year. After this game, the Jaguars will head on the road for a game against the San Francisco 49ers.

Jaguars Looking For Bounce Back

Trevor Lawrence has thrown for 449 yards, 4 touchdowns and 3 interceptions on 58.9% passing while Travis Etienne Jr. leads the Jaguars on the ground with 214 rushing yards. Dyami Brown leads the Jaguars’ receiving group with 8 catches for 109 yards and a touchdown and Travis Hunter has a team-high 9 receptions so far this season. On defense, Foyesade Oluokun has a team-high 17 total tackles while Jacksonville’s defense as a whole has combined for 4 sacks and 5 interceptions so far this season.

Houston Texans @ Jacksonville Jaguars Betting Trends: Week 3

Why the Jacksonville Jaguars will win

Why the Houston Texans will win

Total Points Facts

Jacksonville Jaguars Player Prop Facts

Houston Texans Player Prop Facts

Matchup/League Facts

Houston Texans vs. Jacksonville Jaguars Prediction

I’m on the Texans here. The Texans are a better team than their 0-2 start and in my opinion, they’re a bit unlucky to be sitting at 0-2 on the year. That being said, the offense has struggled out of the gate, but the Jaguars have had issues against this Texans’ defense for the better part of the last few seasons. I think the dog is barking here. Give me the Texans in this one.

Chris Ruffolo's Pick: Houston +1.5

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