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Los Angeles Chargers vs New York Giants Prediction 9/28/2025 Today’s NFL Picks

Sep 21, 2025; Inglewood, California, USA;  Los Angeles Chargers quarterback Justin Herbert (10) throws a pass in the first quarter against the Denver Broncos at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Sep 21, 2025; Inglewood, California, USA; Los Angeles Chargers quarterback Justin Herbert (10) throws a pass in the first quarter against the Denver Broncos at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

MATCHUP Chargers Los Angeles Giants New York
Team Records 3-1 1-3
Where MetLife Stadium, East Rutherford, NJ
When Sunday, September 28, 2025
Time 01:00 PM EDT
TV CBS

The Los Angeles Chargers and the New York Giants meet in week 4 NFL action from MetLife Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. New York Giants prediction.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 23-20 win over the Denver Broncos last time out to start the year at 3-0. After this game, the Chargers will head home for a game against the Washington Commanders.

Chargers Looking To Stay Undefeated

Justin Herbert has thrown for 860 yards, 8 touchdowns and an interception on 66.7% passing while Omarion Hampton leads Los Angeles in rushing with 142 rushing yards and a TD this season. Quentin Johnston has 239 receiving yards and 3 touchdowns to lead the Chargers’ group while Keenan Allen has 194 receiving yards and 3 touchdowns with 19 grabs and Ladd McConkey’s added 15 catches and 163 receiving yards as well. On defense, Derwin James Jr. has a team-high 26 total tackles including 18 solo tackles while Daiyan Henley has a pair of sacks and an interception while the Chargers’ defensive unit as a whole has combined for 7 sacks and 3 interceptions so far this season. 

New York Giants Recap

The New York Giants come into this game looking to rebound from their 22-9 loss at the hands of the Kansas City Chiefs last time out to sit at 0-3 this season. After this game, the Giants will head on the road for a game against the New Orleans Saints.

Giants Still Searching For First W

Russell Wilson has thrown for 778 yards, 3 touchdowns and 3 interceptions on 59.1% passing while also rushing for 94 rushing yards. Cam Skattebo also has 102 rushing yards with 2 touchdowns while Malik Nabers leads the Giants with 16 catches for 251 yards and 2 touchdowns and Wan’Dale Robinson has 15 grabs for 223 yards and a TD. On defense, Bobby Okereke has a team-high 34 total tackles including 15 solo tackles while Paulson Adebo has 27 total tackles including a team-high 23 solo tackles. Brian Burns also leads the Giants with 4 sacks as well this season. 

Los Angeles Chargers @ New York Giants Betting Trends: Week 4

Why the New York Giants will win

Why the Los Angeles Chargers will win

Total Points Facts

New York Giants Player Prop Facts

Los Angeles Chargers Player Prop Facts

Matchup/League Facts

Los Angeles Chargers vs. New York Giants Prediction

I’m on the Chargers here. Not always easy to lay points on the road and the Giants have announced the QB change to Jaxson Dart, so that could give the Giants a bit of a jolt offensively and there’s no real tape on Dart in the NFL. However, the Chargers are still a really tough defense to go up against in your NFL regular season debut, and the Chargers have looked really stout on defense and really consistent on offense. I’ll side with the Chargers in this one.

Chris Ruffolo's Pick: Los Angeles Chargers -6

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