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Los Angeles Rams vs Philadelphia Eagles Prediction 9/21/2025 Today’s NFL Picks

Sep 14, 2025; Kansas City, Missouri, USA; Philadelphia Eagles running back Saquon Barkley (26) reacts during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images

Sep 14, 2025; Kansas City, Missouri, USA; Philadelphia Eagles running back Saquon Barkley (26) reacts during the second half against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images

MATCHUP Rams Los Angeles Eagles Philadelphia
Team Records 2-1 3-0
Where Lincoln Financial Field, Philadelphia, PA
When Sunday, September 21, 2025
Time 01:00 PM EDT
TV FOX

The Los Angeles Rams and Philadelphia Eagles meet Saturday in NFL action at Lincoln Financial Field. Here’s a Los Angeles Rams vs Philadelphia Eagles Prediction. This article will include a Los Angeles Rams vs Philadelphia Eagles Pick.

Los Angeles Rams Betting Preview

The Los Angeles Rams beat the Texans and Titans, and they play the Colts next. The Rams have won 11 of their last 14 regular season games. Matthew Stafford is completing 71 percent of his passes for 543 yards, 3 touchdowns, and 1 interception. Puka Nacua and Davante Adams have combined for 378 receiving yards and 1 touchdown, while Jordan Whittington has 2 receptions.

The Los Angeles Rams ground game is averaging 110.5 yards per contest, and Kyren Williams leads the way with 132 yards and 1 touchdown. Defensively, Los Angeles is allowing 14 points and 258.5 yards per game. Nate Landman leads the Los Angeles Rams with 18 tackles, Byron Young has 3 sacks and Cobie Durant has 1 interception.

Philadelphia Eagles Betting Preview

The Philadelphia Eagles beat the Cowboys and Chiefs, and they play the Buccaneers next. The Philadelphia Eagles have won 14 of their last 15 regular season games. Jalen Hurts is completing 75.6 percent of his passes for 253 yards, 0 touchdowns, and 0 interceptions. DeVonta Smith and Jahan Dotson have combined for 132 receiving yards on 11 catches, while Dallas Goedert has 7 receptions.

The Philadelphia Eagles ground game is averaging 140 yards per contest, and Saquon Barkley leads the way with 148 yards and 2 touchdowns. Defensively, Philadelphia is allowing 18.5 points and 300.5 yards per game. Zack Baun leads the Philadelphia Eagles with 15 tackles, Moro Ojomo has 1 sack and Andrew Mukuba has 1 interception.

Los Angeles Rams @ Philadelphia Eagles Betting Trends: Week 3

Why the Philadelphia Eagles will win

Why the Los Angeles Rams will win

Total Points Facts

Philadelphia Eagles Player Prop Facts

Los Angeles Rams Player Prop Facts

Matchup/League Facts

Los Angeles Rams vs Philadelphia Eagles Prediction

The Eagles have been a fantastic regular season team dating back to last season so they’re going to get the benefit of doubt at home. However, the Eagles have been a bit underwhelming through 2 games, as both games have come down to the wire, and they have yet to get their passing attack going.

I’m a huge fan of Sean McVay, and like backing him in the underdog role, as I believe he gives his team a chance to win each week. In fact, the Rams have covered 10 of their last 14 games as an underdog. Six of those covers were outright wins. The Rams have a top-five passing defense and total defense, so this doesn’t feel like a spot where the Eagles get going. Give me the points.

Randy Chambers's Pick: Los Angeles Rams +3

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