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New Orleans Saints vs Seattle Seahawks Prediction 9/21/2025 Today’s NFL Picks

Sep 14, 2025; Pittsburgh, Pennsylvania, USA;  Pittsburgh Steelers linebacker Jack Sawyer (33) sacks Seattle Seahawks quarterback Sam Darnold (14) during the fourth quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

Sep 14, 2025; Pittsburgh, Pennsylvania, USA; Pittsburgh Steelers linebacker Jack Sawyer (33) sacks Seattle Seahawks quarterback Sam Darnold (14) during the fourth quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

MATCHUP Saints New Orleans Seahawks Seattle
Team Records 0-3 2-1
Where Lumen Field, Seattle, WA
When Sunday, September 21, 2025
Time 04:05 PM EDT
TV CBS

In this article, we will formulate a Saints vs Seahawks Prediction for this NFL Week 3 game on Sunday, September 21st at the Lumen Field. Let’s take a look at the prediction for this NFL matchup.

Seattle Seahawks Preview

Seattle has a 1-1 record this season and are coming off a 31-17 road victory in Pittsburgh. Offensively, the Seahawks average 22.0 points per game, which ranks 16th in the league. Defensively, they allow 17.0 points per game, which ranks 7th. Seattle averages 312.5 total yards per game, with 100.5 rushing yards and 212.0 passing yards per game. They allow 325.5 total yards per game, 95.5 of them rushing and 230.0 passing yards per game.

Sam Darnold leads the Seahawks with 38/56 completed passes and 445 total passing yards. He also adds 14 rushing yards. Kenneth Walker III leads the team in rushing yards, with 125 and 1 touchdown, while Zach Charbonnet adds 57 rushing yards and 1 touchdown. Jaxon Smith-Njigba has a team-high 17 caught passes for a team-high 227 receiving yards. Cooper Kupp has caught 9 passes for 105 yards.

Defensively, Ernest Jones has a team-high 18 total tackles, 11 of them solo. Byron Murphy leads the Seahawks in sacks, with 1.5, while Coby Bryant has 1 interception, Ernest Jones has 1 interception, Josh Jobe has 1 interception, and Derion Kendrick has 1 interception.

New Orleans Saints Preview

New Orleans has a 0-2 record this season and are coming off a 21-26 home defeat by San Francisco. Offensively, the Saints average 17.0 points per game, which ranks 26th in the league. Defensively, they allow 23.0 points per game, which ranks 17th. New Orleans averages 311.0 total yards per game, with 114.0 rushing yards and 197.0 passing yards per game. They allow 310.0 total yards per game, 111.5 of them rushing and 198.5 passing yards per game.

Spencer Rattler leads the Saints with 52/80 completed passes and 421 total passing yards. He also adds 43 rushing yards. Alvin Kamara leads the team in rushing yards, with 144 and 1 touchdown, while Spencer Rattler adds 43 rushing yards. Juwan Johnson has a team-high 13 caught passes for a team-high 125 receiving yards, and has 1 touchdown. Chris Olave has caught 13 passes for 108 yards.

Defensively, Demario Davis has a team-high 20 total tackles, 11 of them solo. Pete Werner adds 14 total tackles, 12 of them solo. Carl Granderson leads the Saints in sacks, with 3.5, while the Saints had no interception in the game.

New Orleans Saints @ Seattle Seahawks Betting Trends: Week 3

Why the Seattle Seahawks will win

Why the New Orleans Saints will win

Total Points Facts

Seattle Seahawks Player Prop Facts

New Orleans Saints Player Prop Facts

Matchup/League Facts

Saints vs Seahawks Prediction

In their most recent meeting back in 2022, New Orleans won 39-32 at home, covering the spread. The Saints have their last four meetings against the Seahawks, but both teams are tied 3-3 wins in their last 6 meetings in Seattle. Under is 4-2 in their last 6 meetings.  

In this Saints vs Seahawks Prediction, the Seahawks are coming as -7.5-point home favorites, with the total set at 41.5 points. The Saints are looking terrible so far, having lost and failed to cover both of their games, losing by an average of 6 points per game. On the flip side, Seattle bounced back after a defeat in their season opener, and are looking for their first home win this season. They have the 7th-best defense in the league, and I don’t think they will have a problem against a struggling Saints squad. Take the Seattle Seahawks and lay the -7.5 points at home.

Nikos Lagouretos's Pick: Seattle -7.5

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