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Tennessee Titans vs Houston Texans Prediction 9/28/2025 Today’s NFL Picks

Tennessee Titans defensive tackle Jeffery Simmons (98) heads out for warmups before the game against the Indianapolis Colts at Nissan Stadium in Nashville, Tenn., Sunday, Sept. 21, 2025.

Tennessee Titans defensive tackle Jeffery Simmons (98) heads out for warmups before the game against the Indianapolis Colts at Nissan Stadium in Nashville, Tenn., Sunday, Sept. 21, 2025.

MATCHUP Titans Tennessee Texans Houston
Team Records 0-4 1-3
Where NRG Stadium, Houston, TX
When Sunday, September 28, 2025
Time 01:00 PM EDT
TV CBS

The Tennessee Titans and Houston Texans meet Sunday in NFL action at NRG Stadium. Here’s a Tennessee Titans vs Houston Texans Prediction. This article will include a Tennessee Titans vs Houston Texans Pick.

Tennessee Titans Betting Preview

The Tennessee Titans lost to the Colts and Rams, and they play the Cardinals next. The Tennessee Titans have lost 9 straight games. Cam Ward is completing 54.5 percent of his passes for 506 yards, 2 touchdowns, and 1 interception. Chig Okonkwo and Calvin Ridley have combined for 231 receiving yards on 20 catches, while Elic Ayomanor has 10 receptions.

The Tennessee Titans ground game is averaging 88.7 yards per contest, and Tony Pollard leads the way with 197 yards and 1 touchdown. Defensively, Tennessee is allowing 31.3 points and 373.7 yards per game. Cody Barton leads the Tennessee Titans with 20 tackles, Jeffery Simmons has 1 sack and Xavier Woods has 1 interception.

Houston Texans Betting Preview

The Houston Texans lost to the Buccaneers and Jaguars, and they play the Ravens next. The Houston Texans have lost 5 of their last 6 regular season games. C.J. Stroud is completing 64 percent of his passes for 599 yards, 2 touchdowns, and 3 interceptions. Nico Collins and Dalton Schultz have combined for 277 receiving yards and 2 touchdowns, while Xavier Hutchinson has 7 receptions.

The Houston Texans ground game is averaging 95 yards per contest, and Nick Chubb leads the way with 141 yards and 1 touchdown. Defensively, Houston is allowing 17 points and 315.7 yards per game. Azeez Al-Shaair leads the Houston Texans with 25 tackles, Will Anderson Jr. has 3 sacks and Jalen Pitre has 1 interception.

Tennessee Titans @ Houston Texans Betting Trends: Week 4

Why the Houston Texans will win

Why the Tennessee Titans will win

Total Points Facts

Houston Texans Player Prop Facts

Tennessee Titans Player Prop Facts

Matchup/League Facts

Tennessee Titans vs Houston Texans Prediction

The Texans are going to get the benefit of the doubt because they’re supposed to be better than their record, and they’re led by a quarterback who has shown things. The Titans are a mess across the board, and Ward is taking his licks as a rookie quarterback. With that said, the Texans are what they are until proven otherwise, and I’m not backing them in the big favorite role regardless of opponent. The Texans are awful offensively and actually dead last in scoring. The Texans are 4-10-1 ATS in their last 15 games when favorites of 5 or more points. This is a fade of the Texans more than anything. Give me the Titans and the points.

Randy Chambers's Pick: Tennessee Titans +6.5

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