Manchester City vs Southampton 5/10/25 Prediction English Premier League Picks

Manchester City will visit Southampton on Saturday, May 10, 2025, at the St. Mary’s Stadium in this Week 36 Premier League Matchup. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Manchester City vs Southampton Prediction. We will examine:

Southampton recent form and player performance

Manchester City recent form and player performance

Recent betting trends and streaks involving Southampton

Recent betting trends and streaks involving Manchester City

Recent betting trends in games played between the Manchester City and Southampton

A summary that ties it all together and produces a favorable betting outcome for Manchester City vs Southampton game

Southampton Preview

Southampton has only 11 points this season and is sitting on the last place of the Premier League standings, and have already been relegated. Southampton has a 2-28-5 record this season and have a terrible 1-14-2 home record. Southampton is coming off a 0-2 road defeat by Leicester City, and have lost 8 of their last 10 matches. Over is 5-1 in their last 6 home games.

Southampton is averaging just 0.71 goals per game, which is the worst in the league, while allowing 2.34 goals per game, which is also ranks last. Paul Onuachu is the top scorer for Southampton this season with 4 total goals. Mateus Fernandes is Southampton’s best passer, with 3 total assists.

Manchester City Preview

Manchester City has 64 points this season and is sitting on the third place of the Premier League standings. Manchester City has a 19-9-7 record this season and are 7-6-4 on the road. They are coming off a 1-0 home victory over Wolves, and are now 7-0-1 in their last 8 games across all competitions. Under is 5-2 in their last 7 overall games, but over is 5-1 in their last 6 road games.

Manchester City is averaging 1.91 goals per game, which is the second-best in the league, while allowing 1.23 goals per game, which is tied for 6th. Erling Haaland is the top scorer for Manchester City this season with 21 total goals, while Phil Foden follows with 7 goals scored. Savio is the team’s top passer, with 8 assists made.

Why Manchester City will win

• Manchester City has won each of its last four EPL matches.
• Manchester City has won each of its last 13 EPL matches against promoted teams.
• Southampton has lost 15 of its last 18 EPL matches.
• Southampton has lost 11 of its last 12 EPL home matches.
• The favorite has won 12 of Southampton’s last 13 EPL matches at St. Mary’s.

Total Points Facts

• The ‘Both Teams to Score’ market has failed to hit in each of Manchester City’s last five EPL matches as an away favorite.
• The ‘Both Teams to Score’ market has hit in six of Southampton’s last eight EPL matches.
• The ‘Both Teams to Score’ market has hit in three of Southampton’s last four EPL home matches.
• The ‘Both Teams to Score’ market has failed to hit in eight of Manchester City’s last 11 EPL matches.
• The ‘Over 2.5 Goals’ market has hit in seven of Southampton’s last eight EPL home matches.
• The ‘Over 2.5 Goals’ market has hit in 14 of Southampton’s last 17 EPL matches.
• The ‘Under 2.5 Goals’ market has hit in each of Manchester City’s last four EPL matches as an away favorite.

Manchester City vs Southampton Prediction

In their previous meeting earlier this season, Manchester City won 1-0 at home. Manchester City is 7-1-1 in their last 9 overall meetings against Southampton, and 3-1-1 in their last 5 meetings in St. Mary’s Stadium. Under is 4-2 in their last 6 meetings in St. Mary’s Stadium.

In this Manchester City vs Southampton Prediction, Manchester City is coming as massive -450 road favorites. Manchester City is rightfully favored, as they have by far the better team this season, and still have something to play for, as they want to hold onto the top-5 of the Premier League that leads to next season’s Champions League.

There is no value in such a huge moneyline, and the only way to back Manchester City to win, is by taking them with a -1.75 or -2 Asian Handicap. City is in peak form with seven wins in their last eight games, and they will have no trouble blowing out Southampton in this one. Take Manchester City with a -1.75 Asian Handicap in this one.

Nikos Lagouretos's Pick: Manchester City -1.75