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Philadelphia Phillies vs Arizona Diamondbacks Prediction 9/21/2025 Today’s MLB Picks

Sep 4, 2025; Milwaukee, Wisconsin, USA; Philadelphia Phillies starting pitcher Ranger Suarez (55) throws against the Milwaukee Brewers in the first inning at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

Sep 4, 2025; Milwaukee, Wisconsin, USA; Philadelphia Phillies starting pitcher Ranger Suarez (55) throws against the Milwaukee Brewers in the first inning at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

MATCHUP Phillies Philadelphia Diamondbacks Arizona
Team Records 92-64 79-77
Where Chase Field, Phoenix, Arizona
When Sunday, September 21, 2025
Time 04:10 PM EDT
TV MLB.TV

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Sunday, September 21st at the Chase Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 78-77 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 41-36 home record and are 74-72 in over/under They are coming off a 4-3 home victory over the Phillies, that ended their two-game losing streak. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .251 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 164 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, and leads the team in home runs with 31.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has an 8-8 record, 5.12 ERA and 1.56 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 92-63 record this season and are sitting on the first place of the NL East. They have a 41-39 road record, and are 69-76 in over/under. They are coming off a 3-4 road defeat by the Dbacks, that ended their four-game winning streak. They are playing the Twins and the Marlins next.

The Phillies have a .260 batting average this season, .330 OBP and .432 Slugging percentage. Philly’s pitching staff has a 3.85 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 129 RBI and a team-high 53 home runs.

Ranger Suarez (L) is the projected starting pitcher for the Phillies, and he has a 12-6 record, 2.84 ERA and 1.17 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 21, 2025

Why the Arizona Diamondbacks will win

Why the Philadelphia Phillies will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Philadelphia Phillies Player Prop Facts

Matchup/League Facts

Phillies vs Diamondbacks Prediction

The Phillies are 3-2 in their last 5 head-to-head meetings against the Diamondbacks, but the Dbacks are 4-1 in their last 5 meetings in Arizona.

In this Phillies vs Diamondbacks Prediction, the Phillies are coming as -135 road favorites. The Phillies have a huge pitching advantage in this game, as they are putting Suarez on the mound, who has been elite this season, and even better on the road, with a 2.25 ERA. On the flip side, Rodriguez has been terrible for the Dbacks, and even weaker at home, with a 5.56 ERA. Suarez has been lights out lately, having won his last 5 starts, with a 1.20 ERA in that span, while the Dbacks have the league’s third-worst bullpen ERA. Take the Philadelphia Phillies to getb the job done on the road in a reasonable price in this one.

Nikos Lagouretos's Pick: Philadelphia Phillies -135

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