White Sox vs Yankees Prediction 9/24/2025 Today’s MLB Picks

In this article we will formulate a White Sox vs Yankees prediction for this MLB game on Wednesday, September 24th at Yankee Stadium in New York. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-99 this season after they lost game one by a score of 3-2 on Tuesday night. Chicago led 2-1 in the ninth inning, but the bullpen fell apart in the heartbreaking loss. The White Sox recorded seven hits in the game and they were led by Montgomery, who went 1-4 with one home run and two RBIs in the loss. Chicago started Smith, who allowed five hits and one earned run over 5.0 innings, while Eisert picked up the loss. 

Prior to this series, the White Sox lost two out of three against the Padres and all three against the Orioles. Chicago has lost nine of their last ten games and they are last in the AL Central standings. The Chicago pitching staff has a 4.22 ERA with a 1.36 WHIP and a .248 opponent batting average, while the offense has scored 620 runs with a .232 batting average and a .302 on base percentage this season. Lenyn Sosa has led Chicago with 21 home runs and 71 RBIs, while Andrew Benintendi has added 20 home runs and 63 RBIs this year. The projected starting pitcher for Chicago is Fraser Ellard, who is 0-2 with a 4.50 ERA and a 1.50 WHIP over 16.0 innings pitched this season. 

New York Yankees Betting Preview

The New York Yankees are 89-68 this year after they won game one by a score of 3-2 on Tuesday night. New York led 1-0 in the second inning, but needed two runs to get the victory in the bottom of the ninth. The Yankees recorded 11 hits and they committed one error in the game, while they were led by Wells and Caballero, who both had one RBI in the win. NY started Gil, who allowed four hits and two earned runs over 6.0 innings, while Weaver picked up the win in relief. 

Prior to this series, the Yankees won three out of four against the Orioles and two out of three against the Twins. New York has won six of their last seven games and they are just one game behind Toronto in the AL East. The New York pitching staff has a 3.96 ERA with a 1.26 WHIP and a .231 opponent batting average, while the offense has scored 819 runs with a .250 batting average and a .331 on base percentage this season. Aaron Judge has led New York with 49 home runs and 105 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Max Fried, who is 18-5 with a 2.92 ERA and a 1.11 WHIP over 188.1 innings pitched this year. 

Why the Yankees will beat the White Sox 

The White Sox have lost each of their last seven games against American League opponents.
The Yankees have won eight of their last nine games at Yankee Stadium against teams that held a losing record.
The White Sox have failed to cover the run line in nine of their last 10 night games against American League opponents following a road loss.
The Yankees have covered the run line in four of their last five games after playing the previous day.
The Yankees have led after 5 innings in eight of their last nine games at Yankee Stadium against opponents that held a losing record.
The White Sox have trailed after 3 innings in three of their last four road night games.

Why the White Sox will beat the Yankees 

The White Sox have won each of their last four night games against the Yankees at Yankee Stadium following a road loss.
The Yankees have lost three of their last four home games against AL Central opponents following a home win.
The White Sox have covered the run line in each of their last six night games against the Yankees at Yankee Stadium following a loss.
The Yankees have failed to cover the run line in eight of their last nine home games against American League opponents following a win.

Total Runs Facts

Each of the Yankees’ last five games against American League opponents have gone UNDER the total runs line.
Each of the White Sox’s last four road games have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the White Sox’s last six night games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the last 10 games between the White Sox and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

Aaron Judge has recorded at least one hit in each of his last 11 home appearances against the White Sox after playing the previous day.
Max Fried has recorded seven or more strikeouts in four of his five previous home appearances against AL Central opponents.
Giancarlo Stanton has hit a home run in four of his last six appearances at Yankee Stadium against opponents that held a losing record.
Paul Goldschmidt has recorded a Double in four of his last five appearances at Yankee Stadium against opponents that held a losing record.
Max Fried has recorded a win in nine of his 10 previous appearances against AL Central opponents.

Chicago White Sox Player Prop Facts

Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.
Andrew Benintendi has hit a home run in three of his last seven appearances in night games.

White Sox vs Yankees Prediction 

New York didn’t have a great night at the plate on Tuesday, but they still found a way to win and they are right with Toronto in the AL East. The Yankees are 45-31 at home this year, while the White Sox are 25-51 on the road. Chicago is sitting at 99 losses on the year and they are starting Ellard, who will be an opener. New York is going with Fried, who has allowed two earned runs or fewer in four of his last five starts. There isn’t much value with New York, so I will take the under, as Chicago should have issues at the plate.

David Racey's Pick: Under 8